Hamm, who is blind and unable to walk, and Clov, Hamm's servant, occupy 'a bare interior'. Nagg and Nell, Hamm's parents, are in dustbins in a corner, and sometimes pop up to talk. Clov looks out of the two small windows with a telescope. The world outside seems dead and grey. Daily rituals are performed ad nauseam.
Hamm and Clov repeatedly discuss whether or not Clov will leave, and why he stays.